Anaesthetic pre-assessment of obese patients in obstetrics: challenges in COVID recovery

Introduction: One in five pregnant women in the UKis obese. Obesity is associated with increased risk of both maternal and foetal adverse outcomes. RCOG guidelines [1] recommend that all women with a booking BMI over 40 kg/m2 should be reviewed antenatally by a senior obstetric anaesthetist to guide risk assessment, medical optimisation and shared decision-making. The 2021 MBRRACE report [2] recommends that all women should be reweighed in the third trimester for accurate VTE risk scoring and prophylactic LMWH dosing. In our institution, reconfiguration of hospital areas as part of the COVID-19 response led to loss of designated clinic space for our obstetric anaesthetic clinic. As a result, our practice since has been to initially offer a telephone consultation followed by a face-to-face review if needed. Finding space for the latter has often been a significant logistical challenge. Our project sought to assess whether our practice continued to meet national standards in the wake of these changes. Method(s): Following audit approval, we retrospectively reviewed all women with a BMI >40 kg/m2 undergoing caesarean section (CS) over a six-month period (1/4/22 to 31/9/22). Result(s): 20 women met inclusion criteria (Category 1-3 CS - 12 women;Category 4 CS - 8 women). 100% of patients had booking height, weight and BMI recorded. 20% (4/20) of patients were reweighed in the 3rd trimester. Only 55% (11/20) of patients had been referred to and reviewed in the antenatal obstetric anaesthetic clinic (Figure). Of the 11 patients referred, 6 were referred later than 30 weeks. Of the 9 patients not referred, 8 had a BMI between 40 and 45 kg/m2. By contrast, 87% (6/7) of patients with BMI over 45 kg/m2 were referred and seen. Discussion(s): Our audit showed that we are not meeting national standards. Possible reasons identified were lack of awareness of the RCOG standards and referral criteria (especially for women with a BMI of 40 to 45 kg/m2) and logistical issues in undertaking face-to-face reviews without designated clinic space. Presentation of our results at the joint anaesthetic, obstetric and midwifery governance meeting has helped identify space in the antenatal clinic for face-to-face reviews, to start from March 2023 and to raise awareness of the national standards to ensure referral of all women with a BMI over 40 kg/m2. A reaudit is planned in 6 months. [Figure presented]Copyright © 2023 Elsevier Ltd

Multiple Fano Resonances in Plasmonic Waveguide Based Cavity and Detection of Pathogenic Virus

A technique is implemented for the generation of multiple Fano-resonances in a plasmonic waveguide based rectangular cavity. A rectangular cavity provides four Fano peaks which can further be increased to nine by inserting the metallic bars in it. The trapped surface plasmon polaritons by metallic bars cause the generation of multiple Fano peaks over the wavelength range of 450 nm - 1300 nm. The obtained response is validated through Fano profile and Fano shape parameter is calculated for each resonance peak. The performance of the proposed device is numerically studied as refractive index sensor and method for analyzing the detection of pathogenic virus like SARS-Cov-2 is reported. Out of nine Fano peaks, the best values of sensing performance indices are obtained with full-width, half-maxima of 1.7 nm, quality factor of 405, sensitivity of 1145.71 nm/RIU and figure of merit of 393.25 RIU-1. IEEE

Monkeypox (Mpox) re-emergence: prevalence, diagnostics, countermeasures, and its global effect

While the world is still trying to emerge from the crisis due to the COVID-19 pandemic, and all the nations are trying to nullify the repercussions caused by it;another outbreak known as the monkeypox virus (MPXV) has recommenced. Human monkeypox, a rare viral zoonosis (an infectious disease that can be transferred from non-human animals to humans), is caused by the MPXV, a member of the genus Orthopoxvirus (family Poxviridae, subfamily Chordopoxvirinae). Since eradicating smallpox globally in 1977, monkeypox has been the primary orthopoxvirus infection in humans. On July 14, 2022, the first case in India was reported in the Kollam district of Kerala. It manifests with the same symptoms as smallpox, including flu-like symptoms, fever, malaise, headache, back pain, and a characteristic rash. New medications have shown promising results, but more study is needed for the drug's efficacy in endemic settings. The monkeypox virus is a high-danger pathogen that causes a significant disease for public health. Consequently, there is a pressing need to develop surveillance capabilities that can yield valuable data for creating suitable preventative, preparedness, and response operations. © 2023,.

Exploring nanoselenium to tackle mutated SARS-CoV-2 for efficient COVID-19 management

Despite ongoing public health measures and increasing vaccination rates, deaths and disease severity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new emergent variants continue to threaten the health of people around the world. Therefore, there is an urgent need to develop novel strategies for research, diagnosis, treatment, and government policies to combat the variant strains of SARS-CoV-2. Since the state-of-the-art COVID-19 pandemic, the role of selenium in dealing with COVID-19 disease has been widely discussed due to its importance as an essential micronutrient. This review aims at providing all antiviral activities of nanoselenium (Nano-Se) ever explored using different methods in the literature. We systematically summarize the studied antiviral activities of Nano-Se required to project it as an efficient antiviral system as a function of shape, size, and synthesis method. The outcomes of this article not only introduce Nano-Se to the scientific community but also motivate scholars to adopt Nano-Se to tackle any serious virus such as mutated SARS-CoV-2 to achieve an effective antiviral activity in a desired manner.

An Assessment of Unconventional Monetary Policy During COVID-19 Pandemic in India

We employ event study methodology to analyze the impact of unprecedented unconventional monetary policy (UMP) measures employed by the Reserve Bank of India to fortify monetary transmission mechanism and to restore financial stability. We find that the UMP announcements result in a decline in bond yields and yield spread as well as increase in market capitalization and sectoral portfolio of stock returns. Evaluating the relative efficacy of UMP measures, we find that targeted long-term repo operation announcements are more effective in easing bond yields than mere long-term repo operations. Our findings provide beneficial inference for day-traders and investors as asset prices increase significantly and durable goods producing stock returns found to be higher than those of non-durable goods. The lessons that can be drawn for the emerging market economy central banks, who do not have enough space to conduct conventional monetary policy and even when they do not face zero lower bound interest rate, they still can employ UMP tools to directly influence banks cost of funds, and long-term bond yields and interest rates, and in turn, portfolio of stock returns and investments to stimulate aggregate demand. JEL Classification: C13, C54, E52, E65

Yoga and Physical Exercises as Immunogenic Fortifiers for Coronavirus Vaccine Responses

Background and aim: Coronavirus has emerged as a pandemic leading to pneumonia and death in susceptible populations, especially in immunocompromised hosts and the elderly. Though national governance and drug firms work in cohesion to develop vaccines, the fear and anxiety towards misconceptions about vaccine efficacy and adverse effects lead to underutilization of the vaccines. Though known for its immunogenic responses against infections, conservative lifestyle modifications such as Yoga and physical exercise's synergistic effects with coronavirus vaccine's immunogenic response remains unknown. Methods: We administered a systematic search on the contemporary evidence investigating the immune responses of physical activity or Yoga in three databases: PubMed, Embase and Web of Science. In the present review, we reviewed the empirical evidence that explored the role of Yoga and physical exercise as an immunity booster and extrapolated their effects against coronavirus infection. Results: We found sixteen articles emphasizing physical activity to augment immune responses towards Coronavirus. Discussion and Conclusion: Considering the contemporary evidence, complementary therapies such as Yoga or physical activity are speculated to improve the influenza vaccines' immune responses. We recommend that Yoga and physical exercises be affordable, practical and effective strategies that could be advocated along with vaccination doses. We hope the present review may help readers and policymakers explore complementary therapies that could be administered as adjuncts to vaccine-mediated immunity in combating the deadly pandemic. © 2023 by authors, all rights reserved.

COVID-19 Detection from Pulmonary CT Images using Neural Networks based on Dropout-Driven Hidden Layers

Enhanced diagnosis with considerably good sensitivity and specificity is highly indispensable for COVID-19 diagnosis using radiological data to combat hazardous viral infection. Accuracy of diagnosis is a very important part that helps in further triaging and disease management. Artificial intelligent techniques using Convolutional Neural Networks and their modified alternatives have been recognized to be the salvation in chaotic situations and emergencies. Despite their immense ability to give quality results, they suffer from overfitting problems which have to be reduced by regularizing the networks. Dropout is one such regularization that modifies the network to achieve improved performance by discarding the unwanted nodes in the network layers. A simple neural network architecture inspired by former renowned architectures with dropout-driven hidden layers, CVDNN is built and experimented with for various dropout probabilities (0.1, 0.25, 0.5 and 0.75). The model was also tested with different numbers of dense layers: CVDNN1 with a single dense layer and CVDNN2 with two dense layers of a fixed dropout probability of 0.5 in it. The models are trained and tested with pulmonary computed tomography images to distinguish COVID-19 abnormality against normal cases. The CVDNN2 model presents better functioning with improved performance measures than CVDNN1 with an accuracy of 92.86 % accuracy, 90.21% sensitivity and a specificity of 95.52% for the dataset used. Dropout probabilities of 0.25 and 0.5 present reliable and better results compared to the other values experimented with. Hence a dropout-driven hidden layer can enhance the neural network's performance by choosing either 0.25 or 0.5 preferably for different applications. © 2023 IEEE.

Novel role of 18F- FDG PET/CT in rhinosinonasal mucormycosis in the era of covid-19 infection

Objectives: In the Covid-19 era, there was a surge in the cases of a life-threatening infection of rhinosinonasal mucormycosis. Mucormycosis, popularly known as black fungus, is an infection caused by mycetes mucorales, an aseptate hyphae. Presently, computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used imaging modalities for the management of patients with rhinosinonasal mucormycosis. The present study was aimed to evaluate the role of 18F- FDG PET/CT in the detection of recurrent or residual disease in post-surgical or post antifungal therapy in these patients for further management. Method(s): A total of 10 patients were included in this pilot study of Covid-19 positive patients and histologically proven mucormycosis (by KOH mount). 18F- FDG PET/CT was performed to assess the disease status in 6 postoperative/ post debridement patients and response to antifungal therapy in 4 patients, at an interval of 40 (range = 27-66) days post intervention. Result(s): The mean age of the patients was 45.0 +/- 11.65 years. The male: female ratio was 9:1. The common clinical presentation was ipsilateral facial or orbital pain and swelling. Covid-19 infection was positive in all the patients except one who had CT finding with HRCT score of 10/25 and hence was considered as post Covid-19 infection. Six out of 10 patients were diabetic on oral hypoglycaemic agents or insulin. All patients had a baseline CT/MRI for staging the initial extent of the disease. Surgical debridement was done in 6 out of the 10 patients followed by antifungal therapy (Liposomal Amphotericin B and Pozaconazole). Remaining four patients were treated with antifungal therapy. PET/CTwas performed after an average of 40 days of surgical/medical intervention, in whom clinical symptoms persisted or worsened even on antifungal therapy. 18F-FDG PET/CT showed metabolically active residual disease in all the patients with a mean SUVmax of 9.78 +/- 4.03. Conclusion(s): In the era of ongoing Covid-19 infection, black fungus has been a debilitating disease with high mortality and morbidity. Present study demonstrated that 18F-FDG PET/CT can be an efficient imaging tool for an early surgical/ medical treatment response assessment and restaging.

Insights from establishing a high throughput viral diagnostic laboratory for SARS-CoV-2 RT-PCR testing facility: challenges and experiences.

Background: The World Health Organization declared the coronavirus disease 2019 (COVID-19) a global pandemic on 11 March 2020. Identifying the infected people and isolating them was the only measure that was available to control the viral spread, as there were no standardized treatment interventions available. Various public health measures, including vaccination, have been implemented to control the spread of the virus worldwide. India, being a densely populated country, required laboratories in different zones of the country with the capacity to test a large number of samples and report test results at the earliest. The Indian Council of Medical Research (ICMR) took the lead role in developing policies, generating advisories, formulating guidelines, and establishing and approving testing centers for COVID-19 testing. With advisories of ICMR, the National Institute of Cancer Prevention and Research (NICPR) established a high-throughput viral diagnostic laboratory (HTVDL) for RT-PCR-based diagnosis of SARS-CoV-2 in April 2020. HTVDL was established during the first lockdown to serve the nation in developing and adopting rapid testing procedures and to expand the testing capacity using "Real-Time PCR." The HTVDL provided its testing support to the national capital territory of Delhi and western Uttar Pradesh, with a testing capacity of 6000 tests per day. The experience of establishing a high-throughput laboratory with all standard operating procedures against varied challenges in a developing country such as India is explained in the current manuscript which will be useful globally to enhance the knowledge on establishing an HTVDL in pandemic or non-pandemic times.

3ß-Acetoxy-21α-H-hop-22(29)ene, a novel multitargeted phytocompound against SARS-CoV-2: in silico screening.

The present pandemic disease COVID-19 demands an urgent need for more efficient antiviral drugs against SARS-CoV-2. Computational drug designing and discovery enable us to explore ethnomedicinal plants as a source of various lead molecules that can be used against present and future pathogens. Adiantum latifolium Lam., a common fern, is resistant to pathogens mainly due to the presence of various phytochemicals having antimicrobial properties. In our previous study, 3ß-acetoxy-21α-H-hop-22(29)ene, a terpenoid has been characterized from the methanol extract of leaves of A. latifolium. The manuscript evaluates the antiviral potency of the compound against SARS-CoV-2 through molecular docking method. Proteins essential for SARS-CoV-2 multiplication in host cells are the target sites. The study revealed strong binding affinity of the compound for all the ten proteins selected, including seven nonstructural proteins, two structural proteins and one receptor protein, with a binding energy of -4.67 to -8.76 kcal/mol. MDS and MMPBSA analysis of the best ranked complex further confirmed the results. The multitargeted compound can be considered as a natural lead molecule in drug designing against COVID-19, but requires wet-lab experimentation and clinical trials.Communicated by Ramaswamy H. Sarma.

Assessment of Stress, Anxiety, and Depression Levels Among COVID-19 Positive Patients Admitted in Rural Tertiary Care Hospital

Objective: The aim of the present study was to investigate the psychiatric distress, including stress, anxiety, and depression levels, among COVID-19 positive patients who were admitted between 01 July 2020 to 31 August 2020 to the COVID-19 isolation ward of the Uttar Pradesh University of Medical Sciences, Saifai, Etawah India. Participants included 100 patients, with 55 males and 45 females. The majority of admitted patients (81%) were illiterate. Out of 100 patients, 83 were married, 16 were unmarried, and only 1 was a widow. Method(s): Levels of anxiety, depression, and stress level were noted in admitted patients using Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire (PHQ-9) depression assessment, and Perceived Stress Scale 4 (PSS-4) assessment techniques, respectively. Result(s): Patient Health Questionnaire (PHQ-9) depression assessment results showed minimal, mild, and moderate depression in 9, 25, and 66 patients, respectively, with a 10.6 median score of PHQ-9. Mild, moderate, and severe anxiety (GAD-7 score) was present in 22, 28, and 50 of the patients surveyed. The mean Perceived Stress Scale 4 (PSS-4) was also analyzed, and it reported 6.1 values. The results of the study demonstrated that the patients had a high label of psychiatric distress, but still, admitted patients believe that they will come out from this pandemic condition. Conclusion(s): Although patients claimed psychiatric distress and mental health illness, they still denied the requirement of any mental health professionals to minimize stress levels and were satisfied with the medical facilities available in a hospital located in a rural area.Copyright © 2022 Bentham Science Publishers.

A Review on Covid-19

COVID-19 (Corona Virus Disease 2019) is a matter of concern since the end of the year 2019, when China informed WHO that there is some pneumonia-like disease with unknown causes in Wuhan.Corona disease is related to the SARS-CoV-2 i.e. Severe Acute Respiratory Syndrome Corona Virus 2. SARS CoV-2 is the strain of coronavirus that causes the disease. Coronaviruses are a group of single-stranded viral RNA genome.WHO has declared COVID-19 as pandemic. Among the various varieties of coronavirus, six are known to infect the human host and cause respiratory diseases. Belonging to the family "Coronaviridae", coronavirus causes a broad spectrum of human and animal diseases. In this review, we have worked to possibly cover all the information about coronavirus.Copyright © 2020 Ubiquity Press. All rights reserved.

PREBIOTICS AND PROBIOTICS: A FOCUSED REVIEW OF APPLICATIONS IN RESPIRATORY DISORDERS

The principal function of food is to provide sufficient nutrients to achieve healthy diets and give a sense of fulfillment and health to people. The prevalence, seriousness, predicted patterns and economic effects of chronic respiratory conditions such as asthma, COPD, COVID-19, and other such diseases pose a serious public health challenge. The use of, among many other therapies, antibiotics, immunosuppressants, and radiation can induce alterations and influence the gastrointestinal biome. Therefore, it would be a very enticing choice to re-establish microbial balance and avoid disease if favorable microorganisms are introduced in the GIT. Probiotic and prebiotic ingredients have been the focus of substantial studies in recent decades in human nutrition with therapeutic potentials. The number of studies on possible health advantages that come via the use of probiotics and prebiotics has improved dramatically in the last few years. The concept of probiotic products has emerged from a live active culture that enhances the balance of the intestinal microbiota composition and the immunomodulatory capacity of clearly specified strains, to specific results. Prebiotics are short-chain carbohydrates that beneficially alter the composition or metabolism of intestinal microbiota. Therefore, prebiotics is supposed to improve wellness like probiotics but at the same time are economic, less toxic, and easier to introduce into the diet than probiotics. These are used to prevent and cure different medical problems and to encourage general well-being. © 2023,Carpathian Journal of Food Science and Technology. All Rights Reserved.

Bedside naso-jejunal placement is more difficult, but successful in patients with COVID-19 in critical care: A retrospective service evaluation of a dietitian-led service

The COVID-19 pandemic presented clinical and logistical challenges in the delivery of adequate nutrition in the critical care setting. The use of neuromuscular-blocking drugs, presence of maxilla-facial oedema, strict infection control procedures, and patients placed in a prone position complicated feeding tube placement. We audited the outcomes of dietitian-led naso-jejunal tube (NJT) insertions using the IRIS (Kangaroo, USA) device, before and during the COVID-19 pandemic. NJT placement was successful in 78% of all cases (n = 50), and 87% of COVID-19 cases. Anaesthetic support was only required in COVID-19 patients (53%). NJT placement using IRIS was more difficult but achievable in patients with COVID-19.Copyright © The Intensive Care Society 2023.

ASSOCIATIONS BETWEEN PHYSICAL ACTIVITY AND MENTAL HEALTH AMONG MALAYSIAN ADULTS DURING COVID 19 PANDEMIC IN MALAYSIA

Physical inactivity was recognized as the fourth risk factor of death and the current Covid-19 pandemic had increased the probability of society becoming less physically active. These contributed to adverse mental changes. Therefore, our main objective was to study the association of physical activity and mental health among adults in Malaysia during Covid-19. A cross-sectional study was conducted through an online survey and 1161 Malaysian adults were recruited in the study. DASS 21 and IPAQ 7 questionnaires were used to access their mental health and physical activity among adults in Malaysia. A total of 1161 participants (267 males and 894 female) were included in the study. Overall, there were participants having average depression score of 1.55 (SD=1.54) that comprises of normal (40.1%), mild (11.7%), moderate (19.7%), severe (9.8%) and extremely severe (18.6%). As for anxiety, the average is 1.96 (SD=1.65) that included normal (33.5%), mild (6.9%), moderate (20.4%), severe (8.3%) and extremely severe (30.9%). The average for stress-induced participants was 0.93 (SD=1.31) that consisted of normal (59.9%), mild (10.9%), moderate (11.7%), severe (10.9%) and extremely severe (6.5%). There was a significant association of depression, anxiety and stress levels (DASS-21) with age (p<0.001), marital status (p<0.001) and employment status (p<0.001). There was no significant association between low, moderate and high physical activity with levels of depression, anxiety and stress. Instead, there was significance association between level of depression, anxiety and stress towards sociodemographic characteristic such as age, marital status and employment status © 2022, Malaysian Journal of Public Health Medicine.All Rights Reserved.

Post-COVID Cutaneous Manifestations: A Retrospective Study at a Tertiary Care Centre

Introduction: COVID-19 disease is caused by SARS COV-2 virus. Though it primarily affects the lower respiratory tract, reports have indicated that specific cutaneous manifestations are associated with COVID-19. Objective(s): To evaluate the persistent dermatologic long term sequelae of SARS-CoV-2 infection, among recovered COVID-19 infected patients. Method(s): Baseline data were retrospectively collected from patient's medical records from the department of dermatology over 1 year (January 2021-January 2022), at a designated tertiary care centre. The demographic data, severity of COVID disease, and pre-existing cutaneous and systemic co-morbidities were noted. Dermatologic, hair and nail manifestations were recorded. The results were statistically analyzed. Result(s): Record of total 972 patients were analyzed in our study, with 432 males and 340 females. Out of these, 88 cases (9.05%) had skin manifestations, of which 35 (39.77%) were male, and 53 (60.22%) were females. About 50% of cases experienced long term skin diseases after 6 months of the recovery. The majority, 47 (53.4%) of patients with skin manifestations, were in the age group of 30-50 years, followed by 31 (35.22 %) of patients in the 50 years age and above group. Urticaria and Pruritus were the most common manifestations 26 (29.5%), followed by telogen effluvium 24 (27.7%), herpes zoster 16(18.1%), pityriasis rosea, acneform eruptions, acral erythema, irritant contact dermatitis, palmar keratoderma, aphthous ulcer with lip crackling, eruptive pseudo angiomatosis, aquagenic keratoderma, and others. Conclusion(s): Prevalence of cutaneous, hair and nail manifestations among COVID-19 patients was 88 (9.05%) in our study. More extensive research is required to establish our knowledge on the relation between skin and COVID-19.Copyright © 2023, Dr Yashwant Research Labs Pvt Ltd. All rights reserved.

Lipid based nanocarriers: Production techniques, concepts, and commercialization aspect

Over the past decade, compared to all other macromolecules lipid-based nanocarriers have proven to be an excellent carrier and delivery system for various pharmaceutical drugs of poor bioavailability. In addition to that, they exhibit exceptional qualities such as minimal toxicity, economical scale-up production, great biocompatibility, and high drug loading efficiency. In this study, we have discussed the various types of lipid nanoparticles, such as liposomes, nanostructured lipid carriers, solid lipid nanoparticles, and lipid polymer hybrid nanoparticles. We have also conferred in detail, the composition, shape and size, methods of preparation, advantages, and certain limitations associated with these lipid-based nanocarriers. Additionally, we have exclusively accounted for several examples of lipid-based nanomedicines that have either been approved and commercialized or are under the different phases of clinical trials. The current review overall focuses on the up-to-date research that has recently been published in view of developing lipid-based nanocarriers for various biological applications, including gene therapy, breast cancer therapy, and vaccine development.Copyright © 2022

Ubiquitin-dependent proteolysis, a therapeutic strategy: An interface between health and disease

All eukaryotic cells have a system in place called the ubiquitin-dependent proteolysis system to control protein degradation;nevertheless, any flaws in this system can initiate numerous fatal diseases, including cancer, metabolic problems, neurological disorders and diseases. These health complications interlink with faults in ubiquitin-dependent proteolysis. Ubiquitin assists as a post-translational targeting signal for altering the structure, localization of other proteins, features and functioning styles of the cells and tissues. The ubiquitin ligase standardizes the specific nature of the ubiquitination features and cellular response. The ubiquitin ligase is a critical element of the enzymatic cascade that regulates the part of the multipubiquitin chain to the target or labile protein. Consequently, the attachment of the ubiquitin topology is crucial for regulating healthy growth, differentiation, and protection of cells from damage by xenobiotics, infections, mutations, and environmental stresses. Protein degradation is adopted by the cells as a route to enduringly deactivate proteins. The 26S proteasome is responsible for ATP-dependent protein failure in the cytoplasm and nuclei of eukaryotes. Most proteins are covalently associated with a multi-ubiquitin chain and engage the 26S proteasome. In the testes, the ubiquitin ligases E1, E2, E3, and UBC4 are dynamic. Here, prompt and large protein alterations are essential for a cell to respond to its environment, and a complex web of interrelated events, including control over synthesis, localization, and degradation. The regulator of the cell cycle, receptor processing, growth management, and stress response are all subject to intracellular proteolysis. This chapter focuses on (I) the significant contribution of ubiquitination in the cellular signaling pathways that contract with these external influences;(II) the mechanisms of ubiquitination-deubiquitination that offer the system its high level of selectivity, (III) the role of ubiquitin-dependent degradation in initiating diseases in humans and forthcoming clinical claims developed to employ the cell's built-in proteolytic machinery to cure diseases;(IV) to examine imaginable clinical practices fashioned to exploit the body's own proteolytic machinery to cure the diseases, and analyze the effectiveness of vaccinations, antibodies, and other possible therapies that aim to block SARS-CoV-2 entrance pathways. Lastly, the authors include the most important unanswered queries pertaining to this crucial route. © 2023 Nova Science Publishers, Inc.

FDA approved five-membered ring fused pyrimidine-based derivatives and their biological properties

Pyrimidines-based drugs are one of the most important drugs for novel and recurring viruses, including the coronavirus. This chapter deals with 41 FDA-approved five-membered ring fused pyrimidine-based drugs, their synthetic strategies, and pharmacological activities. © 2023 Elsevier Ltd. All rights reserved.